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US 2006/0142207 A1Published application
Compositions and methods for treating cancer
AssigneeThreshold Pharmaceuticals, Inc.
InventorsGeorge Tidmarsh, Mark Matteuccii, Photon Rao
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Abstract
Methods and compositions are provided for the treatment of cancer that take advantage of the increased uptake of glucose-anti-neoplastic agent conjugates in cancer cells relative to normal cells.
Claims20
A method for treating cancer in a subject, said method comprising administering to said subject an effective amount of a glucose-anti-neoplastic agent conjugate, wherein said glucose-anti-neoplastic agent conjugate has the formula:
- Glc-L-Z, wherein Glc is 2-deoxy-D-glucose or a 2-deoxy-D-glucose derivative;
- L is a non-releasable linkage;
- and Z is an anti-neoplastic agent
(canceled)
(canceled)
A glucose-anti-neoplastic agent conjugate having the formula:
- Glc-L-Z, wherein Glc is 2-deoxyglucose or a 2-deoxyglucose derivative;
- L a non-releasable linking group;
- and Z is an anti-neoplastic agent.
A compound of structure:
- wherein R is SnMe3.
Dependencies are inferred from the claim text.