Pyrrolidine derivatives for use in treating heaptitis c virus infection

A compound having the general structure (I) or (II) as follows:

• R1 represents the side chain of an amino acid or an amino acid derivative, preferably of hydrophobic nature, an alkyl, alkenyl, or alkynyl group having from 1 to 10 carbon atoms, including CH2CH3 and CH2CF3;
• R2, identical or different, represents a hydrogen atom, an alkyl group having from 1 to 10 carbon atoms, a hydroxyl function, an alkoxy group, or an (C2-14)aryloxy group, —R2 may also represent a carbonyl group (═O);
• R3, identical or different, represents the side chain of an amino acid or an amino acid derivative, preferably of hydrophobic nature, an alkyl, alkenyl, or alkynyl group having from 1 to 10 carbon atoms, or a, substituted or not, (C2-14)aryl or (C2-14)aralkyl group, the aryl moiety thereof being optionally interrupted by at least one heteroatom;
• R4 represents a hydrogen atom, an alkyl, alkenyl, or alkynyl group having from 1 to 10 carbon atoms;
• R5 represents a protecting group for the amine function
• R6 and R7 are the same or different and each represents a hydrogen atom or an, linear, branched, or cyclic, alkyl, alkenyl, or alkynyl group having from 1 to 10 carbon atoms or a, substituted or not, (C2-14)aryl or (C2-14)aralkyl group, the aryl moiety thereof being optionally interrupted with at least one heteroatom;
• R8 and R9 are the same or different and each represents a hydrogen atom or an, linear, branched, or cyclic, alkyl, alkenyl, or alkynyl group having from 1 to 10 carbon atoms or a, substituted or not, (C2-14)aryl or (C2-14)aralkyl group, the aryl moiety thereof being optionally interrupted with at least one heteroatom;
• R10 represents an aldehyde (—CHO), an acid group (—COOH), a sulfonic acid (—SO2OH), —COCOOH group, a radical selected in the group consisting of:
• —COR, —COOR, —CONRR′, —COCOOR, —SO2NRR′ (a sulfonamide group), —CONHCOR, —COCONRR′, —CONHSO2R, —CHOHCOR, —CHOHCOOR, —CHOHCON—RR′, R and R′, identical or different, represent an hydrogen atom, a hydroxyl radical, a linear, branched or cyclic alkyl, alkene or alkyne group having from 1 to 10 carbon atoms, an alkoxy group, an amine group or a, substituted or not, (C2-14)aryl, (C2-14)aralkyl, or (C2-14)aralkoxy group, the aryl moiety thereof being optionally interrupted with at least one heteroatom;
• n is 1 or 2;
• their tautomers, optical and geometrical isomers, racemates, salts, hydrates and mixtures thereof.