Compounds and methods for lowering cholesterol levels without inducing hypertrigylceridemia
OwnerVassilis Zannis, Kyriakos Kypreosinventors
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Abstract
This invention provides methods of lowering cholesterol, delaying the onset of atherosclerosis, or treating atherosclerosis in a mammal without inducing hypertriglyceridemia. These methods involve administrating to or expressing in a mammal, an apoE polypeptide or nucleic acid that, when administered to or expressed in a mammal, lowers the total serum cholesterol level without inducing hypertriglyceridemia.
Claims17
A polypeptide comprising at least 150 amino acids and having an amino acid sequence at least 90% identical to a contiguous region of at least 150 amino acids within amino acids 1-259 of a mature, native, human apoE, said polypeptide, when administered to or expressed in a mammal, being capable of lowering the total serum cholesterol level without inducing hypertriglyceridemia.
Dependencies are inferred from the claim text.