Monkey alpha-7 nicotinic acetylcholine receptor and methods of use thereof
AssigneeMemory Pharmaceuticals Corporation
InventorsShaojie Wang, Daguang Wang
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Abstract
Monkey alpha-7 neuronal nicotinic acetylcholine receptor polypeptides, as well as the DNA (RNA) encoding such polypeptides, are disclosed. Also disclosed are methods for utilizing such polypeptides in diagnostic assays for identifying mutations in nucleic acid sequences encoding the polypeptides of the present invention, for detecting altered levels of the polypeptide of the present invention as a means of detecting diseases and methods of screening potential modulators of the novel alpha-7 receptor disclosed herein. Transgenic animals expressing polypeptides disclosed herein are also described.
Claims21
An isolated polynucleotide for a monkey alpha-7 nicotinic receptor, or a mutation thereof.
An isolated polynucleotide for an alpha-7 nicotinic acetylcholine receptor, comprising:
- (a) a polynucleotide sequence set forth in FIG. 1 (SEQ ID NO:
- 1),
- (b) a polynucleotide sequence coding for a polypeptide having the amino acid sequence from amino acid 1-502 or 23-502 as set forth in FIG. 2 (SEQ ID NO:
- 2),
- (c) a polynucleotide sequence coding for a polypeptide having one or more amino acid substitutions in the M2 region of the polypeptide sequence set forth in FIG. 2 (SEQ ID NO:
- 2) from amino acid 1-502 or 23-502, or
- complements thereto.
Dependencies are inferred from the claim text.