Leuprolide acetate and acetylcholinesterase inhibitors or NMDA receptor antagonists for the treatment of alzheimer's disease
AssigneeVoyager Pharmaceutical Corporation
InventorsChristopher Gregory, Patrick Smith
Life of this patent
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Abstract
Methods of treating, mitigating, slowing the progression of, or preventing Alzheimer's Disease include administration of gonadotropin-releasing hormone analogues in combination with acetylcholinesterase inhibitors and/or N-methyl-D-aspartate receptor antagonists.
Claims18
A method of treating, mitigating, slowing the progression of, or preventing Alzheimer's disease, comprising the step of:
- administering a therapeutically effective combination of a gonadotropin-releasing hormone analogue with an acetylcholinesterase inhibitor or an N-methyl-D-aspartate receptor antagonist.
A method of reducing occurrence of aborted cell cycling of terminally differentiated neurons of a patient, comprising the step of:
- administering a therapeutically effective combination of a gonadotropin-releasing hormone analogue with at least one of an acetylcholinesterase inhibitor and an N-methyl-D-aspartate receptor antagonist.
A method of treating, mitigating, slowing the progression of, or preventing Alzheimer's disease, comprising the step of:
- administering a therapeutically effective amount of leuprolide acetate in combination with at least one of a therapeutically effective amount of an acetylcholinesterase inhibitor and a therapeutically effective amount of an N-methyl-D-aspartate receptor antagonist.
A method of treating, mitigating, slowing the progression of, or preventing Alzheimer's disease, comprising the step of:
- administering a therapeutically effective synergistic combination of a gonadotropin-releasing hormone analogue with an acetylcholinesterase inhibitor or an N-methyl-D-aspartate receptor antagonist.
A combination comprising:
- a gonadotropin-releasing hormone analogue and at least one of an acetylcholinesterase inhibitor and an N-methyl-D-aspartate receptor antagonist.
Dependencies are inferred from the claim text.