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US 2006/0141606 A1Published application
Enantioconvergent chemoenzymatic synthesis of (R)-gamma-amino-beta-hydroxybutyric acid ((R)-GABOB)
AssigneeCouncil of Scientific and Industrial Research
InventorsAhmed Kamal, Gollapalli Khanna, Krishnaji Tadiparthi, Ramu Rondla
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Abstract
The present invention particularly relates to a chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile key intermediates for the preparation of (R)-GABOB by lipase mediated kinetic resolution of its racemates and their effective application in the enantioconvergent synthesis of (R)-GABOB.
Claims11
A chemoenzymatic enantioconvergent process for the stereoselective preparation of (R)-GABOB which comprises of
- (i) transesterifying 3-hydroxy-4-trityloxybutanenitrile and separating enantiomers obtained by lipase-mediated kinetic resolution in the presence of lipase and vinyl acetate;
- (ii) transforming (R)-3-acetyloxy-4-trityloxybutanenitrile to (R)-GABOB;
- and
- (iii) transforming (S)-3-hydroxy-4-trityloxybutanenitrile to (R)-GABOB.
1 more element
Dependencies are inferred from the claim text.