Secreted proteins and nucleic acids encoding them
AssigneeMillennium Pharmaceuticals, Inc.
InventorThomas Barnes
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Abstract
The invention concerns cDNA molecules encoding TANGO 180, TANGO 181, TANGO 182, TANGO 183, TANGO 184, TANGO 185, TANGO 186, TANGO 187, TANGO 188, TANGO 189, and TANGO 215, all of which are either secreted or transmembrane proteins. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes. Accordingly, in one aspect, this invention provides isolated nucleic acid molecules encoding a polypeptide of the invention or biologically active portion thereof. The present invention also provides nucleic acid molecules which are suitable as primers or hybridization probes for the detection of nucleic acids encoding a polypeptide of the invention.
Claims22
An isolated nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid molecule comprising a nucleotide sequence which is at least 55% identical to the nucleotide sequence of any of SEQ ID NOs:1-22, 34-43, and ______-______, the cDNA insert of a plasmid deposited with the ATCC as any of Accession Numbers 98899, 98900, and 98901, or a complement thereof;
- b) a nucleic acid molecule comprising a fragment of at least 300 nucleotides of the nucleotide sequence of any of SEQ ID NOs:1-22, 34-43, and ______-______, the cDNA insert of a plasmid deposited with the ATCC as any of Accession Numbers 98899, 98900, and 98901, or a complement thereof;
- c) a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of any of SEQ ID Nos:23-33, 54-63, and ______-______ or an amino acid sequence encoded by the cDNA insert of a plasmid deposited with the ATCC as any of Accession Numbers 98899, 98900, and 98901;
- d) a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of any of SEQ ID NOs:23-33, 54-63, and ______-______ wherein the fragment comprises at least 15 contiguous amino acids of any of SEQ ID NOs:23-33, 54-63, and ______-______ or the polypeptide encoded by the cDNA insert of a plasmid deposited with the ATCC as any of Accession Numbers 98899, 98900, and 98901;
- and
- e) a nucleic acid molecule which encodes a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of any of SEQ ID NOs:23-33, 54-63, and ______-______ or an amino acid sequence encoded by the cDNA insert of a plasmid deposited with ATCC as any of Accession Numbers 98899, 98900, and 98901, wherein the nucleic acid molecule hybridizes to a nucleic acid molecule comprising any of SEQ ID Nos:1-22, 34-43, and ______-______ or a complement thereof under stringent conditions.
An isolated polypeptide selected from the group consisting of:
- a) a fragment of a polypeptide comprising the amino acid sequence of any of SEQ ID Nos:23-33, 54-63, and ______-______, wherein the fragment comprises at least 15 contiguous amino acids of any of SEQ ID Nos:23-33 and 54-63, and ______-______;
- b) a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of any of SEQ ID Nos:23-33, 54-63, and ______-______ or an amino acid sequence encoded by the cDNA insert of a plasmid deposited with the ATCC as any of Accession Numbers 98899, 98900, and 98901, wherein the polypeptide is encoded by a nucleic acid molecule which hybridizes to a nucleic acid molecule comprising any of SEQ ID Nos:1-22, 34-43, and ______-______ or a complement thereof under stringent conditions;
- and
- c) a polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 55% identical to a nucleic acid comprising the nucleotide sequence of any of SEQ ID Nos:1-22, 34-43, and ______-______ or a complement thereof.
Dependencies are inferred from the claim text.