Novel metabolic targets and markers
OwnerSteven Watkins, Rebecca Baillieinventors
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Abstract
The present invention provides metabolic markers and targets, especially PEMT activity and metabolic markers and components associated therewith useful for diagnosing and treating various disease conditions.
Claims22
A method for regulating the level of a fatty acid in a system comprising regulating the phosphatidylethanolamine-N-methyltransferase (PEMT) activity in the system whereby regulating the level of a fatty acid in the system, wherein the fatty acid is selected from the group consisting of 16:0, 18:0, 16:1n7, 18:1n7, 18:2n6, 20:4n6, 20:5n3, 22:6n3, saturated fatty acids, polyunsaturated fatty acids, and highly unsaturated fatty acids.
A method for decreasing the level of a fatty acid in a system comprising decreasing the CDP-choline activity in the system whereby decreasing the level of a fatty acid in the system, wherein the fatty acid is selected from the group consisting of 16:0, 16:1n7, 18:2n6, and saturated fatty acids.
15-16. (canceled)
A method for regulating a lipoprotein component ratio in a system comprising regulating the PEMT activity in the system whereby regulating the lipoprotein component ratio in the system, wherein the lipoprotein component ratio is selected from the group consisting of cholesterol ester to phosphatidylcholine, cholesterol ester to apoprotein, free cholesterol to apoprotein, and triacylglyceride to phosphatidylcholine.
23-156. (canceled)
Dependencies are inferred from the claim text.