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AssigneeBoard of Regents, The University of Texas System
InventorsPhilip Thorpe, Sophia Ran
Estimating the term…
Disclosed are the surprising discoveries that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are stable and specific markers accessible on the luminal surface of tumor blood vessels, and that the administration of an anti-aminophospholipid antibody alone is sufficient to induce thrombosis, tumor necrosis and tumor regression in vivo. This invention therefore provides anti-aminophospholipid antibody-based methods and compositions for use in the specific destruction of tumor blood vessels and in the treatment of solid tumors. Although various antibody conjugates and combinations are thus provided, the use of naked, or unconjugated, anti-phosphatidylserine antibodies is a particularly important aspect of the invention, due to simplicity and effectiveness of the approach.
A kit comprising, in a pharmaceutically acceptable form, biologically effective amounts of at least a first anti-cancer agent, wherein said at least a first anti-cancer agent is at least a first antibody, or an antigen-binding fragment thereof, that binds to an aminophospholipid;
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A therapeutic kit comprising, in at least a first suitable container, a combined pharmaceutically effective amount of:
A kit comprising, in a pharmaceutically acceptable form, biologically effective amounts of at least a first anti-cancer agent, wherein said at least a first anti-cancer agent is at least a first antibody, or an antigen-binding fragment thereof, that binds to phosphatidylethanolamine;
Dependencies are inferred from the claim text.