Compositions, kits and assays containing reagents directed to cortactin and an ARG/ABL protein kinase
OwnerAnthony Koleske, Scott Boyle +3inventors
InventorsAnthony Koleske, Scott Boyle, Greg Michaud, Barry Schweitzer, Paul Predki
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Abstract
It has been determined Cortactin interacts with an ARG/ABL protein kinase. Thus, provided herein are compositions, kits and assays containing reagents directed to Cortactin and an ARG/ABL protein kinase.
Claims30
A method for identifying a molecule that modulates an interaction between an ARG/ABL protein or fragment and a Cortactin protein or fragment, comprising:
- contacting the ARG/ABL protein or fragment and the Cortactin protein or fragment with a test molecule, wherein the ARG/ABL protein or fragment and the Cortactin protein or fragment interact in the absence of the test molecule;
- and
- detecting the presence, absence or amount of an interaction between the ARG/ABL protein or fragment and the Cortactin protein or fragment,
- whereby a difference in the interaction in the presence of the test molecule versus the absence of test molecule identifies the test molecule as a molecule that modulates the interaction.
A method for identifying a molecule that modulates a biological activity in a system containing an ARG/ABL reagent and a Cortactin reagent, comprising:
- contacting the ARG/ABL reagent, the Cortactin reagent and a test molecule in the system;
- and
- detecting the presence, absence or amount of the biological activity,
- whereby a difference in the biological activity in the presence of the test molecule versus the absence of test molecule identifies the test molecule as a molecule that modulates the biological activity.
A kit comprising a Cortactin reagent and an ARG/ABL reagent.
A composition comprising a Cortactin reagent and an ARG/ABL reagent.
Dependencies are inferred from the claim text.