US 2006/0141493 A1 · Atherosclerotic phenotype determinative genes and methods for using the same

Abstract

Genes whose expression is correlated with and determinant of an atherosclerotic phenotype are provided. Genes whose expression is correlated with and determinant of an atherosclerotic susceptibility are also provided. Also provided are methods of using the subject atherosclerotic determinant genes or the atherosclerotic susceptibility genes in diagnosis and treatment methods, as well as drug screening methods. In addition, reagents and kits thereof that find use in practicing the subject methods are provided. Also provided are methods of determining whether a gene is correlated with a disease phenotype, where correlation is determined using at least one parameter that is not expression level and is preferably determined using a binary prediction tree analysis.

Claims19

Dependent claims

A method of estimating whether a sample is from tissue having an atherosclerotic phenotype, said method comprising:

(a) obtaining an expression profile for said sample from at least two of said genes listed in Table I;
(b) providing one or more predictive statistical tree models, each model including one or more nodes, each node representing a metagene, each node including a statistical predictive probability of the having an atherosclerotic phenotype, each metagene representing a dominant factor from a group of genes associated with having an atherosclerotic phenotype, wherein at least two genes in the group of genes are selected from those listed in Table I;
and
(c) determining an estimate of the sample having the atherosclerotic phenotype by averaging the predictions of one or more of the tree models applied to the expression profile of the sample.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

11/198,782Filed 4 Aug 2005

Priority

9 Nov 2001

Published

29 Jun 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

G16B 20/20
ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations: allele or variant detection, e.g. single…
C12Q 1/6883
Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes: for diseases caused by alterations of genetic material
G16B 20/00
Ict specially adapted for functional genomics or proteomics
G16B 40/30
ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge…:…

Family

Application60/337,709Us provisional application · filed 9 Nov 2001

Application60/374,547Us provisional application · filed 23 Apr 2002

Application60/420,784Us provisional application · filed 24 Oct 2002

Application60/421,043Us provisional application · filed 25 Oct 2002

Application60/424,680Us provisional application · filed 8 Nov 2002

Application10/291,885Continuation in part · filed 12 Nov 2002

Application60/651,462Us provisional application · filed 4 Aug 2004

Application11/198,782Continuation in part · filed 4 Aug 2005

US 2003/0224383 A1Published application

US 2006/0141493 A1This patent

From the US filing history. Foreign family members aren’t listed.

Atherosclerotic phenotype determinative genes and methods for using the same

Life of this patent

Atherosclerotic phenotype determinative genes and methods for using the same

Life of this patent

Abstract

Claims19