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US 2006/0141490 A1Published application
MyD88 as a therapeutic target for cancer
OwnerIsabelle Coste-Invernizzi, Toufic Rennoinventors
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Abstract
The invention relates to methods for identifying anti-cancer agents using MyD88 as a therapeutic target.
Claims6
1) A method for identifying an anti-cancer agent comprising:
- a) contacting a test sample with a cell that expresses MyD88 or a biologically active fragment thereof;
- and
- b) measuring MyD88 expression level in said cell,
- whereby the test sample is identified to contain an anti-cancer agent if the test sample causes decreased MyD88 expression when compared to a control cell.
1 more element
3) A method for identifying an anti-cancer agent comprising:
- a) contacting a test sample with a cell having a vector comprising a nucleic acid encoding MyD88 or a biologically active fragment thereof;
- and
- b) measuring MyD88 expression level in said cell,
- whereby the test sample is identified to contain an anti-cancer agent if the test sample causes decreased MyD88 expression when compared to a control cell.
1 more element
5) A method for identifying an anti-cancer agent comprising:
- a) contacting a test sample with a cell having a vector comprising a nucleic acid encoding MyD88 or a biologically active fragment thereof that is operably linked to a reporter gene;
- and
- b) measuring MyD88 expression level in said cell,
- whereby the test sample is identified to contain an anti-cancer agent if the test sample causes decreased MyD88 expression when compared to a control cell.
1 more element
Dependencies are inferred from the claim text.