Electrically active combinatorial chemical (EACC) chip for biochemical analyte detection

A method of detecting an analyte, comprising:

• providing a substrate including an array of regions defining a plurality of cells, each of the plurality of cells including a reaction cavity containing multiple functional binding groups on the gate of a transistor;
• applying a voltage between the source and the drain;
• and
• monitoring a parameter indicative of an analyte characteristic when the voltage is applied.

A method of detecting an analyte, comprising:

• providing a substrate including an array of regions defining a plurality of cells, each of the plurality of cells including a reaction cavity containing multiple functional binding groups between a pair of electrodes;
• applying a voltage between the pair of electrodes;
• and
• monitoring a parameter indicative of an analyte characteristic when the voltage is applied.

A method of making an analyte sensor, comprising:

• providing a substrate including an array of regions defining a plurality of cells each including a reaction cavity;
• coupling multiple functional binding groups to each reaction cavity;
• and
• forming an analyte sensing structure including the substrate with the array of regions.