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US 2006/0141482 A1Published application
Method and multicomponent conjugates for treating cancer
OwnerEssam Awdallainventor
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OwnerEssam Awdallainventor
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The present invention provides a method for treating cancer in a mammal and to multicomponent conjugates useful in such treatment. In particular, it provides a cancer treatment method that includes administering multicomponent conjugates of formula: A-B-C, where “B” may be present or absent, “A” comprises at least one specific anti-cancer binding protein such as an antibody or an antibody binding fragment, or a ligand binding to a receptor present on the outer surface of a cancer cell, “B” comprises at least one molecule to which “A” and “C” bind, such as a biotin-avidin-biotin complex, “C” comprises at least one specific anti-platelet binding protein such as an antibody or an antibody binding fragment, or a ligand binding to a receptor present on the outer surface of a blood platelet. The multicomponent conjugates provide the exquisite binding specificity of antibodies, which enables attaching the blood platelets to the outer surface of cancer cells, and thus, stimulating the formation of blood clots within the blood vessels around and in-between cancer cells, leading to their destruction.
A multicomponent conjugate comprising a formula A-B-C, wherein “A” comprises at least one specific anti cancer binding protein recognizing a receptor present on the outer surface of a cancer cell, “B” comprises at least one molecule to which “A” and “C” bind, and “C” comprises at least one specific anti-platelet binding protein recognizing a receptor present on the outer surface of a blood platelet.
A multicomponent conjugate comprising a formula A-C, wherein “A” comprises at least one specific anti-cancer binding protein recognizing a receptor present on the outer surface of a cancer cell, and “C” comprises at least one specific anti-platelet binding protein recognizing a receptor present on the outer surface of a blood platelet.
In a mammal, a method for destroying cancer cells, comprising administering to said mammal a number of multicomponent conjugates, each having the formula A-C, wherein “A” comprises at least one specific anti-cancer binding protein recognizing a receptor present on the outer surface of the cancer cells, and “C” comprises at least one specific anti-platelet binding protein recognizing a receptor present on the outer surface of a blood platelet.
In a mammal, a method for destroying cancer cells, comprising administering to said mammal a number of multicomponent conjugates, each having the formula A-B-C, wherein “A” comprises at least one specific anti-cancer binding protein recognizing a receptor present on the outer surface of the cancer cells, “B” comprises at least one molecule to which “A” and “C” bind, and “C” comprises at least one specific anti-platelet binding protein recognizing a receptor present on the outer surface of a blood platelet.
Dependencies are inferred from the claim text.