Back to results
US 2006/0141448 A1Published application
Whole cell assay
AssigneeSmithKline Beecham Corporation
InventorsFrank Fan, Yinduo Ji, Howard Kallender, Tong Li, Damien McDevitt
Life of this patent
Estimating the term…
Abstract
This invention relates to newly developed methods for discovering therapeutic compounds using a cell-based assay system. This invention also relates to compositions of matter useful in carrying out the methods of the invention as well as therapeutic compounds developed using such methods.
Claims11
A method for identifying candidate compounds which alter metabolism comprising the steps of:
- providing at least one host cell comprising at least one recombinant regulatable gene;
- contacting said host cell with at least one candidate compound at least one level of induction of gene expression;
- and detecting altered metabolism in said host cell of the contacting step.
A method for identifying candidate compounds which alter metabolism comprising the steps of:
- providing at least one host cell comprising at least one recombinant regulatable gene;
- contacting said host cell in a first contacting step with at least one candidate compound at a first level of induction of gene expression;
- detecting altered metabolism in said host cell of said first contacting step;
- contacting a second host cell or said host cell in a second contacting step with at least one candidate compound at a second level of induction of gene expression;
- and detecting altered metabolism in said host cell of said second contacting step.
2 more elements
Dependencies are inferred from the claim text.