Apparatus and method for transcellular testing
OwnerJ. Gyory, Michael Cima +2inventors
InventorsJ. Gyory, Michael Cima, Javier Gonzalez-Zugasti, Anthony Lemmo
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Abstract
The present invention relates to a device and method for facilitating high throughput transcellular flux testing of compounds, such as pharmaceuticals or drugs, other compounds, or compound combinations. In one embodiment, the system and methods of the present invention may be used to identify the optimal components (e.g., solvents, carriers, transport enhancers, adhesives, additives, inhibitors, or other excipients) for pharmaceutical compositions or formulations that are delivered to a patient via tissue transport, including without limitation, pharmaceutical compositions or formulations administered or delivered transcellularly, topically, and ocularly.
Claims26
1-28. (canceled)
A transcellular testing device, comprising:
- (a) a membrane having a first membrane surface opposing a second membrane surface, wherein said first membrane surface is configured for cellular adhesion;
- and
- (b) a hydrophobic layer having a first hydrophobic layer surface opposing a second hydrophobic layer surface wherein said second hydrophobic layer surface is coupled to said second membrane surface, and wherein said hydrophobic layer comprises at least one discrete independent testing unit having;
- (i) a first opening in said first hydrophobic layer surface;
- (ii) a second opening in said second hydrophobic layer surface;
- and
- (iii) a passageway defined by said hydrophobic layer between said first opening and said second opening.
A method of transcellular testing, comprising:
- (a) providing a membrane having a first membrane surface opposing a second membrane surface, wherein said first membrane surface is configured for cellular adhesion;
- and
- (b) coupling a hydrophobic layer to said second membrane surface wherein said hydrophobic layer defines at least one passageway therethrough.
Dependencies are inferred from the claim text.