Metal coordinated compositions
OwnerThomas Piccarielloinventor
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Abstract
A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof.
Claims36
A metal coordination complex of a biologically active moiety and a metal, wherein
- the biologically active moiety is selected from the group consisting of thyronine, tetracycline antibiotics, dimethylbiguanide, hydrochlorothiazide, acycloguanosine, hydrocodone, oxycodone, and their derivatives, and
- the metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc.
A metal coordination complex of a biologically active moiety and a metal, wherein the biologically active moiety contains a β-diketone, ketophenol or β-ketoalcohol, functional group and
- the metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc.
A metal coordination complex of a biologically active moiety and a metal, wherein
- the biologically active moiety contains an alcohol and an azole functional group, and
- the metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc.
A metal coordination complex of a biologically active moiety and a metal, wherein
- the biologically active moiety contains a guanide or a diamine functional group, and
- the metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc.
A method of modulating the properties of a biologically active moiety comprising
- forming a metal coordination complex with the biologically active moiety and a metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc, wherein
- the biologically active moiety is selected from the group consisting of thyronine, tetracycline antibiotics, hydrocodone, oxycodone, and their derivatives, and
- the metal is selected from the group consisting of aluminum, bismuth, calcium, iron, magnesium, silicon, and zinc.
Dependencies are inferred from the claim text.