Pharmaceutical compositions based on diclofenac derivate
OwnerChristina Gustafsson, Sven Moreininventors
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Abstract
The present invention relates to particles comprising the drug 2-[2-(nitrooxy)ethoxy]ethyl{2-[(2,6-dichlorophenyl)amino]phenyl}acetate, optionally mixed with one or more surfactant(s) and to a new drug delivery composition comprising said particles optionally in combination with a second drug. Furthermore, the invention relates to processes for preparing said particles and drug delivery composition as well as the use of said composition in the manufacturing of a medicament.
Claims26
A drug delivery composition comprising 2-[2-(nitrooxy)ethoxy]ethyl {2-[(2,6-dichlorophenyl)amino]phenyl}acetate in melted form absorbed/adsorbed onto/into particles.
A process for preparing particles comprising 2-[2-(nitrooxy)ethoxy]ethyl{2-[(2,6-dichlorophenyl)amino]phenyl}acetate comprising mixing the drug in melted form with particles.
A process for preparing particles comprising 2-[2-(nitrooxy)ethoxy]ethyl {2-[(2,6-dichlorophenyl)amino]phenyl}acetate comprising:
- a) melting the drug,
- b) adding the particles,
- c) stirring the obtained mixture,
- d) recovering the porous particles comprising the drug.
A process for preparing particles comprising 2-[2-(nitrooxy)ethoxy]ethyl{2-[(2,6-dichlorophenyl)amino]phenyl}acetate comprising:
- a) mixing the drug with the particle,
- b) melting the obtained mixture,
- c) stirring the obtained mixture,
- d) recovering the particles comprising the drug.
A process for preparing particles comprising 2-[2-(nitrooxy)ethoxy]ethyl{2-[(2,6-dichlorophenyl)amino]phenyl}acetate and one or more surfactant(s) comprising:
- a) melting the drug and the surfactant(s),
- b) adding the particles,
- c) stirring the obtained mixture,
- d) recovering the particles comprising the drug and the surfactant(s),
- with a) and b) in optional order.
Dependencies are inferred from the claim text.