Pharmaceutical compositions containing abiguanide-glitazone combination
OwnerAnupam Trehan, Sumit Madan +2inventors
InventorsAnupam Trehan, Sumit Madan, Vinod Arora, Rajiv Malik
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Abstract
The present invention relates to an orally administered pharmaceutical composition that is a combination of two or more antidiabetic agents in which one of the antidiabetic agents is present in an extended release form and the other antidiabetic agent is present in an immediate release form.
Claims94
A solid pharmaceutical dosage form for oral administration, the dosage form comprising:
- an extended release layer comprising a biguanide;
- and
- an immediate release layer comprising a glitazone.
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A process for preparing a solid, orally administered pharmaceutical dosage form of an extended release core of a biguanide and an immediate release layer of a glitazone, the process comprising:
- a. dispersing the biguanide in a solid matrix to form a core having a surface;
- and
- b. layering the immediate release layer of the glitazone on the surface of the core.
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A process for preparing a bilayered, solid, orally administered pharmaceutical dosage form of a biguanide and a glitazone, the process comprising:
- a. dispersing the biguanide in an extended release carrier base material;
- b. separately dispersing the glitazone in an immediate release carrier base material;
- and
- c. compressing the material of step a and step b to form bilayered tablet.
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A method of treating non-insulin dependent diabetes mellitus in a patient in need thereof, the method comprising administering a solid, pharmaceutical dosage form of the combination of a biguanide and a glitazone, wherein the dosage form provides an extended-release of the biguanide and an immediate release of the glitazone.
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Dependencies are inferred from the claim text.