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AssigneeDrugtech Corporation
InventorsJonathan Bortz, R. Levinson, Mitchell Kirschner, Robert Cuca
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A pharmaceutical composition comprises (a) an antibacterial agent in an antibacterially effective amount, illustratively comprising clindamycin or a pharmaceutically acceptable salt or ester thereof, and (b) an antifungal agent in an antifungally effective amount, illustratively comprising butoconazole or a pharmaceutically acceptable salt or ester thereof. The composition is adapted for application in a unit dose amount to a vulvovaginal surface and has at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface. The composition is useful for administration to a vulvovaginal surface to treat a mixed bacterial vaginosis and vulvovaginal candidiasis infection.
A pharmaceutical composition comprising:
The delivery system of claim 21, wherein the applicator is disposable.
The delivery system of claim 21, wherein the applicator is prefilled with a unit dose amount of the composition.
The delivery system of claim 23, wherein the unit dose amount of the composition is about 1 to about 10 g.
The delivery system of claim 23, wherein the unit dose amount of the composition is about 3 to about 6 g.
A method for treating a mixed bacterial vaginosis and vulvovaginal candidiasis infection, the method comprising administering to a vulvovaginal surface a pharmaceutical composition comprising:
The method of claim 26, wherein:
The method of claim 26, wherein the vulvovaginal surface to which the composition is administered is a vaginal mucosal surface.
The method of claim 28 wherein the composition is applied in a single dosage amount effective to provide an acceptable clinical response.
The method of claim 29, wherein the single dosage amount is about 1 to about 10 g.
Dependencies are inferred from the claim text.