Anesthetic composition for topical administration
OwnerFernando Fitainventor
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Abstract
It comprises a mixture of lidocaine, prilocaine and tetracaine, or their pharmaceutically acceptable salts. The preferred composition comprises the following components in the indicated approximate w/w percentages: 1.5% of lidocaine base; 1.5% of prilocaine base; 4% of tetracaine base; 10% of methylpynrolidone; 2% of dimethyl sulfoxide; 0.08% of topical hyaluronidase; 1.5% of guar gum; 1% of Tween-20; 0.5% of Tween-80, and the necessary amount of water to 100%. It exhibits a a high concentration on skin, a deep anesthetic effect and a significantly more rapid onset of the anesthetic effect than comparable transdermal anesthetics.
Claims26
A pharmaceutical composition for topical administration comprising:
- (i) a therapeutically safe and effective amount of lidocaine or of a pharmaceutically acceptable salt thereof;
- (ii) a therapeutically safe and effective amount of prilocaine or of a pharmaceutically acceptable salt thereof;
- and
- (iii) a therapeutically safe and effective amount of tetracaine or of a pharmaceutically acceptable salt thereof.
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A pharmaceutical composition for topical administration comprising the following components in the indicated approximate w/w percentages:
- 1.5% of lidocaine base;
- 1.5% of prilocaine base;
- 4% of tetracaine base;
- 10% of methylpyrrolidone;
- 2% of dimethyl sulfoxide;
- 0.08% of topical hyaluronidase;
- 1.5% of guar gum;
- 1% of Tween-20;
- 0.5% of Tween-80, and the necessary amount of water to 100%.
A method of use of a combination comprising lidocaine, prilocaine and tetracaine, any of which being as such or as a pharmaceutically acceptable salt, for the preparation of a topical anesthetic pharmaceutical composition;
- the method comprising:
- providing a combination of lidocaine, prilocaine and tetracaine themselves or as pharmaceutically acceptable salts thereof;
- and,
- administering the combination topically.
Dependencies are inferred from the claim text.