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AssigneeThe Trustees of the University of Pennsylvania
InventorsDavid Weiner, Karuppiah Muthumani
Estimating the term…
Genetic constructs that comprise a coding sequence for HIV-1 Rev, and a coding sequence for a desired protein are disclosed. Compositions that comprise at least two nucleic acid molecules in which at least one nucleic acid molecule comprises a coding sequence for HIV-1 Rev, and at least one nucleic acid molecule comprises a coding sequence for a desired protein are disclosed. In such genetic constructs and compositions comprising nucleic acid molecules, the coding sequence for the desired protein comprises at least a portion of coding sequence for an HIV structural protein that includes an RRE and at least one CTE. Methods of inducing an immune response against an immunogen in an individual, methods of delivering proteins to an individual and methods of producing proteins are also disclosed.
A genetic construct that comprises:
A composition comprising at least two nucleic acid molecules:
A method of inducing an immune response against an immunogen in an individual comprising the step of administering to said individual either:
A method of delivering a protein to an individual comprising the step of administering to said individual either:
A method of producing a protein in a cell comprising the step of culturing a cell comprises either:
Dependencies are inferred from the claim text.