Trivalent vaccine with material antibody transfer via the milk
AssigneeAkzo Nobel N.V.
InventorsThomas Gore, Adrian Mockett
Life of this patent
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Abstract
Embodiments of the present invention generally relate to novel multivalent vaccines and methods of vaccinating. In an embodiment, the present invention is a trivalent vaccine for canine herpesvirus (CHV), canine rotavirus (CRV), and Minute virus of canine (MVC) or other canine parvovirus delivered to pups of a whelp through colustrums and providing sufficient antibody titer to impart protection.
Claims27
A multivalent vaccine able to be administered to a bitch prior to whelping comprising a first antigen, a second antigen, and a third antigen wherein an effective amount of maternal antibody to each antigen is transferred at nurse to at least one pup of the bitch and wherein each of the first antigen, the second antigen and the third antigen are different.
The vaccine of claim 27 wherein the first antigen, the second antigen and the third antigen are selected from the group consisting of live, attenuated lives,, killed, and any combination of the aforementioned.
The vaccine of claim 27 wherein the nurse is performed within a time selected from twenty-four (24) hours and forty-eight (48) hours from whelp.
The vaccine of claim 27 wherein the titer of CHV one week post whelp is greater than about 1:32.
The vaccine of claim 27 wherein the titer of CRV one week post whelp is greater than about 1:128.
The vaccine of claim 27 wherein the titer of MVC one week post whelp is greater than about 1:32.
The vaccine of claim 27 wherein the titer of CHV two weeks post whelp is greater than about 1:32.
The vaccine of claim 27 wherein the titer of CRV two weeks post whelp is greater than about 1:128.
The vaccine of claim 27 wherein the titer of MVC two weeks post whelp is greater than about 1:32.
A method of vaccinating a puppy against at least one of canine herpesvirus (CHV), canine rotavirus (CRV), and Canine Parvovirus (CPV), selected from the group consisting of Minute virus of canine (MVC, CPV-1) and Canine Parvovirus (CPV-2) comprising the steps of administering a vaccine to the bitch prior to whelp comprising a CHV antigen, a CRV antigen, and/or a CPV antigen and allowing at least one of the puppies to nurse within about forty-eight (48) hours of whelp.
A method of vaccinating a puppy for protection against canine herpesvirus (CHV), canine rotavirus (CRV), and Canine Parvovirus (CPV), selected from the group consisting of Minute virus of canine (MVC, CPV-1) and Canine Parvovirus (CPV-2) comprising the steps of vaccinating a bitch with a vaccine comprising an antigen of CHV, an antigen of CRV, and an antigen of CPV prior to whelp and administering colostrums of the bitch to at least one puppy within about forty-eight (48) hours of whelp whereby maternal antibodies are transferred at a sufficiently high titer to protect the puppy from disease caused by CHV, CRV and CPV.
A multivalent vaccine able to be administered to a bitch prior to whelping comprising a first antigen comprising canine herpesvirus (CHV), a second antigen comprising canine rotavirus (CRV), and a third antigen comprising canine parvovirus (CPV), selected from the group consisting of Minute virus of canine (MVC, CPV-1) and Canine Parvovirus (CPV-2), wherein an effective amount of maternal antibody to each antigen is transferred at nurse to at least one pup of the bitch and wherein each of the first antigen, the second antigen and the third antigen are different.
Dependencies are inferred from the claim text.