Hypoallergenic polypeptides based on fish parvalbumin
AssigneeBIOMAY Produktions- und Handels-Aktiengesellschaft
InventorsRudolf Valenta, Peter Valent, Susanne Spitzauer, Ines Swoboda
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Abstract
The present invention relates to non-naturally occurring polypeptides derived from fish allergens such as parvalbumin Cyp c 1.01 from carp. The polypeptides display reduced allergenic activity and are useful as allergy vaccines for treatment of sensitized allergic patients and for prophylactic vaccination.
Claims21
A non-naturally occurring polypeptide derived from fish parvalbumin, selected from the group consisting of
- (a) polypeptides comprising an amino acid sequence in which in respect to the amino acid sequence as shown in SEQ ID NO:1 one to 15 amino acid residues are deleted, substituted and/or added;
- (b) polypeptides comprising a fragment of (a), wherein the fragment has a length of at least 15 amino acids and at least 90% of the amino acid residues of the fragment are identical to corresponding residues of the amino acid sequence as shown in SEQ ID NO:1;
- (c) polypeptides comprising a fragment of the amino acid sequence as shown in SEQ ID NO:1, wherein the fragment has a length of at least 15 amino acids;
- (d) polypeptides consisting of a fragment of (a), wherein the fragment has a length of at least 10 amino acids and at least 80% of the amino acid residues of the fragment are identical to corresponding residues of the amino acid sequence as shown in SEQ ID NO:1;
- and
- (e) polypeptides consisting of a fragment of the amino acid sequence as shown in SEQ ID NO:1, wherein the fragment has a length of at least 10 amino acids.
A mutated polypeptide comprising an amino acid sequence selected from the group consisting of the sequences as shown in SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and SEQ ID NO:6.
A mutated polypeptide derived from a fish parvalbumin, wherein in respect to the wild type sequence of the fish parvalbumin amino acid positions have been substituted or deleted which correspond to the amino acid residues which are substituted or deleted in respect to SEQ ID NO:1 in SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5 or SEQ ID NO:6.
14-17. (canceled)
Dependencies are inferred from the claim text.