Immunogenic peptides for the treatment of prostate and breast cancer
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsJay Berzofsky, Sangkon Oh, Ira Pastan
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Abstract
Immunogenic T-cell receptor gamma Alternate Reading Frame Protein (TARP) polypeptides are disclosed herein. These immunogenic TARP polypeptides include nine consecutive amino acids of the amino acid sequence set forth as SEQ ID NO: 9 and do not comprise amino acids 1-26 or amino acids 38-58 of SEQ ID NO: 1. Several specific, non-limiting examples of these polypeptides are set forth as SEQ ID NOs: 3-7. Nucleic acids encoding these polypeptides, and host cells transfected with these nucleic acids, are also disclosed. Methods of using these polypeptides, and polynucleotides encoding these polypeptides, for the treatment of breast and prostate cancer are also disclosed.
Claims48
An isolated polypeptide comprising nine consecutive amino acids of the amino acid sequence set forth as SEQ ID NO:
- 9 wherein the polypeptide does not comprise amino acids 1-26 or amino acids 38-58 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.