Immunogenic acute phase protein-antigenic molecule complexes and fusion proteins
AssigneeUniversity of Connecticut Health Center
InventorPramod Srivastava
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Abstract
The present invention relates to complexes and fusion proteins comprising an acute phase protein and an antigenic molecule, for use in the treatment or prevention of a disease. The invention specifically provides for complexes comprising an acute phase protein noncovalently bound to, or alternatively crosslinked to, an antigenic molecule. The invention also specifically provides fusion proteins comprising an acute phase protein fused via a peptide bond to an antigenic molecule.
Claims15
A purified complex comprising an antigenic molecule cross-linked to an acute phase protein, wherein the complex is free of biological cells and vesicles, and wherein the acute phase protein is not α-2 macroglobulin.
A method for preparing in vitro complexes of an acute phase protein associated with one or more antigenic molecules comprising cross-linking an acute phase protein to one or more antigenic molecules using a cross-linking agent.
A method of treating or preventing cancer or an infectious disease in a subject comprising administering to the subject an amount of a purified complex comprising an antigenic molecule cross-linked to an acute phase protein effective to treat or prevent cancer or an infectious disease, wherein the complex is free of biological cells and vesicles, the acute phase protein is not α-2 macroglobulin, and the antigenic molecule displays the antigenicity of a cancer-associated or cancer-specific antigen, or of an antigen of an infectious agent that causes the infectious disease, respectively.
A method of inducing an immune response against an antigenic molecule in a subject comprising administering to the subject an immunogenic amount of a purified complex comprising said antigenic molecule cross-linked to an acute phase protein, wherein the complex is free of biological cells and vesicles, and wherein the acute phase protein is not α-2 macroglobulin.
A method of treating a disease or disorder amenable to treatment by induction of an immune response against an antigenic molecule comprising administering to a subject having the disease or disorder an immunogenic amount of a purified complex comprising the antigenic molecule cross-linked to an acute phase protein, wherein the complex is free of biological cells and vesicles, and wherein the acute phase protein is not α-2 macroglobulin.
Dependencies are inferred from the claim text.