Tumour necrosis factor binding ligands
OwnerDeborah Rathjen, Roger Astoninventors
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Abstract
Provided are isolated antibodies or fragments thereof which bind a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of mature human TNF-α. The antibodies and fragments thereof may be used to identify antibodies capable of binding in the region of mature human TNF-α of amino acid resides 22-40. Antibodies or fragments thereof which bind particular regions of mature human TNF-α are shown to elicit particular biological activities dependent upon the particular region wherein binding occurs.
Claims60
An isolated antibody or fragment thereof which binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
An isolated antibody or fragment thereof which binds mature human TNF-α, and binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
A composition comprising an isolated antibody or fragment thereof which binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
A composition comprising an isolated antibody or fragment thereof which binds mature human TNF-α, and binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
An isolated single chain antibody which binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
An isolated single chain antibody which binds mature human TNF-α, and binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
A composition comprising an isolated single chain antibody which binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
A composition comprising an isolated single chain antibody which binds mature human TNF-α, and binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
An isolated single domain antibody or fragment thereof which binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
An isolated single domain antibody or fragment thereof which binds mature human TNF-α, and binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
A composition comprising an isolated single domain antibody or fragment thereof which binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
A composition comprising an isolated single domain antibody or fragment thereof which binds mature human TNF-α, and binds a peptide consisting of residues Ala22-Glu23-Gly24-Gln25-Leu26-Gln27-Trp28-Leu29-Asn30-Arg31-Arg32-Ala33-Asn34-Ala35-Leu36-Leu37-Ala38-Asn39-Gly40 (peptide 307) of the mature human TNF-α amino acid sequence.
Dependencies are inferred from the claim text.