Tumour necrosis factor binding ligands
OwnerDeborah Rathjen, Roger Astoninventors
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Abstract
Provided are isolated antibodies or fragments thereof which bind a peptide consisting of residues His73-Val74-Leu75-Leu76-Thr77-His78-Thr79-Ile80-Ser81-Arg82-Ile83-Ala84-Val85-Ser86-Tyr87-Gln88-Thr89-Lys90-Val91-Asn92-Leu93-Leu94 (peptide 309) of mature human TNF-α. The antibodies and fragments thereof may be used to identify antibodies capable of binding in the region of mature human TNF-α of amino acid resides 73-94. Antibodies or fragments thereof which bind particular regions of mature human TNF-α are shown to elicit particular biological activities dependent upon the particular region wherein binding occurs.
Claims30
An isolated antibody or fragment thereof which binds a peptide consisting of residues His73-Val74-Leu75-Leu76-Thr77-His78-Thr79-Ile80-Ser81-Arg82-Ile83-Ala84-Val85-Ser86-Tyr87-Gln88-Thr89-Lys90-Val91-Asn92-Leu93-Leu94 (peptide 309) of mature human TNF-α.
A composition comprising an isolated antibody or fragment thereof which binds a peptide consisting of residues His73-Val74-Leu75-Leu76-Thr77-His78-Thr79-Ile80-Ser81-Arg82-Ile83-Ala84-Val85-Ser86-Tyr87-Gln88-Thr89-Lys90-Val91-Asn92-Leu93-Leu94 (peptide 309) of mature human TNF-α.
An isolated single chain antibody which binds a peptide consisting of residues His73-Val74-Leu75-Leu76-Thr77-His78-Thr79-Ile80-Ser81-Arg82-Ile83-Ala84-Val85-Ser86-Tyr87-Gln88-Thr89-Lys90-Val91-Asn92-Leu93-Leu94 (peptide 309) of mature human TNF-α.
A composition comprising an isolated single chain antibody which binds a peptide consisting of residues His73-Val74-Leu75-Leu76-Thr77-His78-Thr79-Ile80-Ser81-Arg82-Ile83-Ala84-Val85-Ser86-Tyr87-Gln88-Thr89-Lys90-Val91-Asn92-Leu93-Leu94 (peptide 309) of mature human TNF-α.
An isolated single domain antibody or fragment thereof which binds a peptide consisting of residues His73-Val74-Leu75-Leu76-Thr77-His78-Thr79-Ile80-Ser81-Arg82-Ile83-Ala84-Val85-Ser86-Tyr87-Gln88-Thr89-Lys90-Val91-Asn92-Leu93-Leu94 (peptide 309) of mature human TNF-α.
A composition comprising an isolated single domain antibody or fragment thereof which binds a peptide consisting of residues His73-Val74-Leu75-Leu76-Thr77-His78-Thr79-Ile80-Ser81-Arg82-Ile83-Ala84-Val85-Ser86-Tyr87-Gln88-Thr89-Lys90-Val91-Asn92-Leu93-Leu94 (peptide 309) of mature human TNF-α.
Dependencies are inferred from the claim text.