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US 2006/0140950 A1Published application
Uses of mammalian cytokine; related reagents
AssigneeSchering Corporation
InventorsDaniel Cua, Yi Chen, Robert Kastelein, Claire Langrish, Donna Rennick, Jonathon Sedgwick
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Abstract
Provided are methods of treatment for inflammatory and autoimmune disorders of the central nervous system and gastrointestinal tract. Also provided are methods of diagnosis.
Claims20
A method of treating an IL-23 mediated disorder comprising administering an effective amount of an:
- a) agonist of IL-23;
- or
- b) antagonist of IL-23.
A purified or isolated IL-17 producing CD4+ T cell that upon treatment with IL-23 has a 10-fold higher expression of at least one gene of Table 10B when compared to treatment with IL-12.
Dependencies are inferred from the claim text.