Novel polypeptides involved in immune response
AssigneesAmgen Inc., Amgen Canada Inc.
InventorsSteven Yoshinaga, Tak Mak, Arda Shahinian, Anna Bladt, Giorgio Senaldi
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Abstract
Novel polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing same are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
Claims9
1-31. (canceled)
A method of decreasing IgE production in an animal comprising administering a B7RP1 antagonist in an amount effective to decrease IgE production.
A method of preventing or treating an IgE-mediated disorder comprising administering a therapeutically effective amount of a B7RP1 antagonist.
(canceled)
39-42. (canceled)
Dependencies are inferred from the claim text.