Immunotherapy using modulators of notch signalling
OwnerBrian Champion, Roberto Solari +4inventors
InventorsBrian Champion, Roberto Solari, Margaret Dallman, Jonathan Lamb, Gerard Hoyne, Emmanuel Cyrille Briend
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Abstract
There is provided a use of a modulator of Notch signalling for the preparation of a medicament for treatment of Graft Versus Host Disease (GVHD) and diseases and conditions caused by or associated with transplants such as organ, tissue and/or cell transplants (e.g. bone marrow transplants), wherein the modulator is used to reduce the reactivity of cells of the immune system.
Claims17
A method of treating Graft Versus Host Disease (GVHD) in a subject comprising administering a modulator of Notch signalling to the subject.
A method of preparing donor cells for use in a transplant comprising:
- (i) isolating an antigen presenting cell (APC) from a transplant patient;
- (ii) exposing the APC to a modulator of Notch signalling;
- and
- (iii) incubating the APC with APCs or lymphocytes from a transplant donor.
A method of preparing donor cells for use in a transplant comprising:
- (i) isolating an APC or lymphocyte from a transplant donor;
- (ii) exposing the APC or lymphocyte to a modulator of Notch signalling;
- and
- (iii) incubating said APC or lymphocyte with APCs from a transplant patient.
Dependencies are inferred from the claim text.