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AssigneeBristol-Myers Squibb Company
InventorsGlen Mikesell, Han Chang, Joshua Finger, Guchen Yang, Robert Peach
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The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.
1-52. (canceled)
An isolated polynucleotide sequence comprising a nucleic acid sequence selected from the group consisting of:
An isolated polynucleotide sequence comprising the cDNA clone contained in plasmid BSL3 in ATCC Deposit No. PTA-1986.
An isolated polynucleotide sequence consisting of a nucleic acid sequence selected from the group consisting of:
An isolated polynucleotide consisting of amino acids 1 to 217 of SEQ ID NO:14 further comprising the Fc domain of an immunoglobulin.
Dependencies are inferred from the claim text.