Repairing or replacing tissues or organs
AssigneeThe General Hospital Corporation
InventorsRakesh Jain, Dai Fukumura
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Abstract
In general, this invention provides methods and compositions for stabilizing, repairing, or replacing damaged or diseased tissues or organs by engineering blood vessels in such tissues or organs. In addition, the invention further provides methods and compositions for producing functional microvascular networks useful in tissue engineering.
Claims80
A method for inducing blood vessel formation or engineering blood vessels in a tissue or organ of a mammal, said method comprising administering one or more cells selected from the group consisting of preadipocytes, adipocytes not having a genetic modification, perivascular cells, vascular smooth muscle cells, mesenchymal precursor cells, mesenchymal cells, and fibroblasts to a tissue or organ of a mammal in need of increased blood vessel formation or engineered blood vessels.
A method for increasing blood vessel formation or engineering blood vessels in a tissue or organ, said method comprising administering one or more cells selected from the group consisting of perivascular cells, vascular smooth muscle cells, mesenchymal precursor cells, mesenchymal cells, and fibroblasts to a tissue or organ in need of increased blood vessel formation or engineered blood vessels.
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Dependencies are inferred from the claim text.