Methods for inducing an immune response via oral administration of an adenovirus
OwnerHildegund Ertlinventor
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Abstract
The present invention provides a method for inducing an immune response to an adenovirus in a subject which has been pre-exposed to an adenovirus or adenoviral vector. The invention further provides a method for inducing a mucosal immune response to an antigen. The methods of the invention are carried out by oral administration of adenoviral vectors.
Claims22
A method for inducing an immune response to a transgene product in a subject pre-exposed to an adenovirus or adenoviral vector comprising orally administering to a subject, that has been exposed to a first adenovirus or adenoviral vector, an effective amount of a second adenoviral vector encoding a transgene product so that an immune response to the transgene product is induced.
A method for inducing an immune response to a transgene product comprising orally administering to a subject an effective amount of a first adenoviral vector encoding a transgene product and subsequently systemically administering to the subject an effective amount of a second adenoviral vector encoding said transgene product.
A method for inducing an immune response in an infant comprising orally administering to an infant an effective amount of an adenoviral vector encoding a transgene product so that an immune response to the transgene product is induced.
A method for inducing a mucosal immune response to an antigen comprising:
- orally administering an effective amount of a first adenoviral vector containing nucleic acid sequences encoding an antigen, and
- orally administering an effective amount of a second adenoviral vector containing said nucleic acid sequences encoding said antigen,
- so that a mucosal immune response is induced.
Dependencies are inferred from the claim text.