Affinity proteins for controlled application of cosmetic substances
AssigneeL-MAbs B.V.
InventorsErwin Houtzager, Irma Vijn, Peter Sijmons, Grant Mudge, Addi Fadel
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Abstract
Provided are means and methods for applying a cosmetic substance to a desired target. The method comprises providing a conjugate of a proteinaceous substance having a specific affinity for the target molecule linked to a cosmetic substance, whereby the resulting connection between the cosmetic substance and the target molecule can be disrupted upon the presence of a chemical and/or physical signal.
Claims46
A method for applying a cosmetic substance to a desired target molecule, said method comprising:
- providing a conjugate of a proteinaceous substance having specific affinity for said target molecule linked to a cosmetic substance, wherby wherein the resulting connection between said cosmetic substance and said target molecule can be disrupted upon the presence or application of a chemical and/or physical signal.
A conjugate comprising a proteinaceous substance having specific affinity for a target molecule linked to a cosmetic substance, wherein the resulting connection between cosmetic substance and target molecule can be disrupted upon the presence of a chemical and/or physical signal, and further wherein said proteinaceous substance comprises a synthetic or recombinant proteinaceous molecule comprising a binding peptide and a core, said core comprising a beta-barrel comprising at least four strands, wherein said beta-barrel comprises at least two beta-sheets, wherein each of said beta-sheets comprises two of said strands and wherein said binding peptide is a peptide connecting two strands in said beta-barrel and wherein said binding peptide is outside its natural context.
A divalent or multivalent proteinaceous substance having specific affinity for at least two target molecules present in hair and wherein epitopes recognized on said at least two target molecules may be the same or different.
Dependencies are inferred from the claim text.