Semi-soft C-class immunostimulatory oligonucleotides
AssigneesColey Pharmaceutical Group, Inc., Coley Pharmaceutical GmbH
InventorsArthur Krieg, Ulrike Samulowitz, Jorg Vollmer, Eugen Uhlmann
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Abstract
The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infectious disease, such as hepatitis B and hepatitis C.
Claims63
An oligonucleotide comprising:
- 5′ TC_GTC_GTN1TC_GGCGCN1GCCG 3′ (SEQ ID NO:
- 27), wherein the oligonucleotide includes at least 2 stabilized internucleotide linkages and _ represents phosphodiester or phosphodiester-like internucleotide linkage and wherein N1 is 0-3 nucleotides in length, with N referring to any nucleotide.
An oligonucleotide comprising:
- 5′ TC_GTC_GAC_GATC_GGCGC_GCGCCG 3′ (SEQ ID NO:
- 4), wherein the oligonucleotide includes at least 2 stabilized internucleotide linkages and _ represents phosphodiester or phosphodiester-like internucleotide linkage.
An oligonucleotide comprising:
- 5′ TTC_GTC_GTTTX1—GTC_GTT 3′ (SEQ ID NO:
- 25), wherein the oligonucleotide includes at least 2 stabilized internucleotide linkages and _ represents phosphodiester or phosphodiester-like internucleotide linkage and wherein X1 is a pyrimidine.
An oligonucleotide comprising:
- TCGTCGTTCGGCGCGCCG (SEQ ID NO:
- 3).
An oligonucleotide comprising:
- TCGTCGTCGTTCGGCGCGCGCCG (SEQ ID NO:
- 2).
An oligonucleotide comprising:
- TCGTCGACGATCGGCGCGCGCCG (SEQ ID NO:
- 4).
An oligonucleotide comprising:
- TTCGTCGTTTTGTCGTT (SEQ ID NO:
- 5).
An oligonucleotide comprising:
- TTTCGTCGTTTCGTCGTT (SEQ ID NO:
- 6).
An oligonucleotide comprising:
- T*C_G*T*C_G*T*C, wherein * represents a stabilized internucleotide linkage and _ represents phosphodiester or phosphodiester-like internucleotide linkage.
An oligonucleotide comprising:
- T*C_G*T*T*C_G*G, wherein * represents a stabilized internucleotide linkage and _ represents phosphodiester or phosphodiester-like internucleotjde linkage.
Dependencies are inferred from the claim text.