Stable aerosol formulations of peptides and protein with non-cfc propellants
OwnerMarc Brown, Stuart Jones +2inventors
InventorsMarc Brown, Stuart Jones, Gary Martin, Yong-Hong Liao
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Abstract
Glycosidicaily stabilised macromolecules, such as proteins and peptides, have substantially greater stability in the presence of hydrofluoroalkane propellants for dispensing from metered dose inhalers, when formulated with polyhydroxylated polyalkenes such as PVA.
Claims29
A formulation of a therapeutic substance suitable for delivery to a patient by a metered dose inhalation device, the formulation comprising a substantially dry powder preparation of the substance in association with a stabilising amount of a carbohydrate compound or derivative thereof and a polyhydroxylated polyalkene in combination with one or more propellants therefor, wherein the therapeutic substance is selected from peptides and proteins.
Dependencies are inferred from the claim text.