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OwnerNikolai Zefirov, Andrei Afanasiev +8inventors
InventorsNikolai Zefirov, Andrei Afanasiev, Svetlana Afanasieva, Sergei Bachurin, Sergei Tkachenko, Vladimir Grigoriev, Marina Jurovskaya, Valery Chetverikov, Elizaveta Bukatina, Irina Grigorieva
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Compounds and methods of using these compounds to treat neurodegenerative diseases, especially Alzheimer's disease, are provided. The compounds that are provided for the treatment of neurodegenerative diseases can be represented by a general formula (I): wherein R1 is Me, Et or PhCH2; R2 is H, PhCH2 or 6-Me-3-Py-(CH2)2; and R3 is H, Me or Br. The solid line accompanied by the dotted line i.e. represents a single or double bond and salts thereof with pharmacologically acceptable acids and quaternary derivatives.
A method of measuring the accuracy of NMDA injection into a mouse brain comprising co-injecting methylene blue and NMDA into the mouse brain and monitoring the migration of methylene blue.
Dependencies are inferred from the claim text.