Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same
AssigneeNanocarrier Co., Ltd.
InventorsNaoya Shibata, Yukio Nagasaki, Kazunori Kataoka
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AssigneeNanocarrier Co., Ltd.
InventorsNaoya Shibata, Yukio Nagasaki, Kazunori Kataoka
Estimating the term…
This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show decreased non-specific adsorption of protein or the like. Said latex polymer particles are produced by making latex-forming monomer, macromer which has at least a hydrophilic polymer segment and an inorganic fluorescent substance or an inorganic contrast medium co-existent simultaneously in an aqueous medium, and subjecting them to a polymerization reaction.
A process to produce fluorescent substance-containing latex polymer particles, characterized in that polymerization reaction is conducted in an aqueous medium while the aqueous medium is stirred, said aqueous medium comprises:
Hydrophobic core-hydrophilic shell type latex polymer particles which include, in their hydrophobic core domain, inorganic fluorescent substance or inorganic contrast medium, said latex polymer particles having an average particle size of 0.001 to 5 μm, and being formed by radical polymerization in an aqueous medium which comprises:
Dependencies are inferred from the claim text.