US 2006/0137030 A1 · Protein tyrosine phosphatase RPTP-beta disruptions, compositions and methods relating thereto

Abstract

The present invention relates to compositions and methods relating to the characterization and function of RPTPB. Specifically, the present invention provides transgenic animals comprising disruptions in a RPTPB gene and methods of treating diseases conditions, such as depression. The present invention further relates to agents that modulate RPTPB and methods of screening for agents that modulate RPTPB for the treatment of diseases and conditions such as depression.

Claims1

Dependent claims

A transgenic mouse comprising a disruption in an endogenous RPTPB gene.

Dependencies are inferred from the claim text.

Facts

Application

11/348,606Filed 6 Feb 2006

Priority

6 Dec 2000

Published

22 Jun 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C12N 15/8509
For animal cells: for producing genetically modified animals, e.g. transgenic
A01K 67/0276
Genetically modified vertebrates, e.g. transgenic: knock-out vertebrates
C12N 9/16
Hydrolases: acting on ester bonds
A01K 2217/072
Animals genetically altered by homologous recombination: maintaining or altering function, i.e. knock in

Family

Application60/251,897Us provisional application · filed 6 Dec 2000

Application60/302,260Us provisional application · filed 28 Jun 2001

Application10/005,220Continuation in part · filed 4 Dec 2001

Application10/167,243Continuation in part · filed 10 Jun 2002

Application10/326,600Continuation · filed 20 Dec 2002

Application10/326,600Continuation in part · filed 20 Dec 2002

Application11/348,606Continuation · filed 6 Feb 2006

US 2003/0106083 A1Published application

US 2006/0137030 A1This patent

From the US filing history. Foreign family members aren’t listed.

Abstract

Facts

Application

11/348,606Filed 6 Feb 2006

Priority

6 Dec 2000

Published

22 Jun 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C12N 15/8509
For animal cells: for producing genetically modified animals, e.g. transgenic
A01K 67/0276
Genetically modified vertebrates, e.g. transgenic: knock-out vertebrates
C12N 9/16
Hydrolases: acting on ester bonds
A01K 2217/072
Animals genetically altered by homologous recombination: maintaining or altering function, i.e. knock in

Family

Application60/251,897Us provisional application · filed 6 Dec 2000

Application60/302,260Us provisional application · filed 28 Jun 2001

Application10/005,220Continuation in part · filed 4 Dec 2001

Application10/167,243Continuation in part · filed 10 Jun 2002

Application10/326,600Continuation · filed 20 Dec 2002

Application10/326,600Continuation in part · filed 20 Dec 2002

Application11/348,606Continuation · filed 6 Feb 2006

US 2003/0106083 A1Published application

US 2006/0137030 A1This patent

From the US filing history. Foreign family members aren’t listed.

Protein tyrosine phosphatase RPTP-beta disruptions, compositions and methods relating thereto

Life of this patent

Abstract

Claims1

Protein tyrosine phosphatase RPTP-beta disruptions, compositions and methods relating thereto

Life of this patent

Abstract

Claims1