Modulators of ribosomal function and identification thereof

A method of identifying a molecule that binds to a large ribosomal subunit, the method comprising the steps of:

• (a) providing a molecular model comprising one or more target regions selected from the group consisting of at least a portion of (i) a peptidyl transferase site, (ii) an A-site, (iii) a P-site, (iv) an E-site, (v) an elongation factor binding domain, (vi) a polypeptide exit tunnel, and (vii) a signal recognition particle (SRP) binding domain, from the atomic co-ordinates for Haloarcula marismortui large ribosomal subunit found on Disk 1 under file name 1JJ2.txt, or PDB1FFK.txt, or deposited at the Protein Data Bank under accession number PDB ID:
• 1JJ2 or 1FFK, or derived from said Haloarcula marismortui atomic co-ordinates by molecular modeling;
• and
• (b) using the molecular model to identify a candidate molecule that can bind to the one or more target regions in the molecular model.

A method of identifying a molecule that binds to a large ribosomal subunit, the method comprising the steps of:

• (a) providing a molecular model comprising one or more target regions selected from the group consisting of a peptidyl transferase site, an A-site, a P-site, an E-site, an elongation factor binding domain, a polypeptide exit tunnel, and a signal recognition particle (SRP) binding domain, from the atomic co-ordinates (i) for Haloarcula marismortui large ribosomal subunit found on Disk 1 under file name 1JJ2.Ptxt, or PDB1FFK.txt, or deposited at the Protein Data Bank under accession number PDB ID:
• 1JJ2 or 1FFK, or (ii) derived from the Haloarcula marismortui atomic co-ordinates by molecular modeling;
• and
• (b) using the molecular model to identify a candidate molecule that can bind to the one or more target regions in the molecular model.