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OwnerKuo-Jang Kao, Hsun-Chih Kuo +1inventors
InventorsKuo-Jang Kao, Hsun-Chih Kuo, Andrew Huang
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A method of normalizing gene expression data obtained on a given microarray for a particular biological samples, comprising sorting said data as a function of expression degree for each gene, sorting a reference standard of gene expression data according to the same function of expression degree, and normalizing the expression degree of said particular gene expression data to the corresponding value in the reference standard, the reference standard having been obtained from gene expression data which is other than said particular gene expression data. The method is applicable for normalizing data obtained on a given microarray under varying conditions, including updates in associated instrumentation.
A method of normalizing gene expression data obtained on a given microarray for a particular biological sample comprising normalizing said data using reference standard gene expression data, which was obtained on a microarray containing the same genes as said given microarray by measuring expression of said genes from different sets of biological samples different from said particular sample, averaging expression data for each gene within said sets to calculate reference standard expression values for said genes for each set, and determining that the correlations of said reference standard values among said sets are sufficiently highly significant that the reference standard values for each set are essentially identical.
A method of normalizing gene expression data obtained on a given microarray for a particular biological sample, comprising sorting said data as a function of expression degree for each gene, sorting a reference standard of gene expression data according to the same function of expression degree, and normalizing the expression degree of said particular gene expression data to the corresponding value in the reference standard, the reference standard having been obtained from gene expression data which is other than said particular gene expression data.
A reference standard for quantile normalization of gene expression data comprising the gene expression data of the file “Reference Standards.txt” in the appended CD.
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