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AssigneeLars Laboratoire D'Application Et De Recherche Sci
InventorsBernard Brulez, Jacques-Philippe Laboreau, Veronique Migonney, Mihaela Ciobanu, Graciela Pavon-Djavid, Alain Siove
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Biomimetic artificial prostheses which are made from polyester, such as polyethylene terephthalate, and a method for the biomimetic functionalization of such prostheses. The method includes a step involving the grafting of biologically-active polymers or copolymers to the polyester surface of the prostheses, the grafting step consisting of the peroxidation of the surface by ozonation followed by a step including the radical polymerization of a solution of at least one monomer. The method also includes an optional step consisting in impregnating the prostheses with type I and/or II collagen and/or fibronectins. The prostheses thus obtained enable a normal and uniform regrowth of the fibroblasts, thereby significantly improving the biological integration of such polyester prostheses.
1-15. (canceled)
A method for treating polyester artificial prostheses, and notably in polyethylene terephtalate, in order to give them the capacity of mimicking living materials and especially of facilitating the anchoring and the development of fibroblasts after implantation of said prostheses, said biomimetic functionalization method characterized in that it includes a first step for preparing the polyester surface in a solvent medium followed by one step for grafting biologically active polymers or copolymers to the polyester surface of said prostheses, which grafting step consists of achieving peroxidation of the surface by ozonation followed by a radical polymerisation of a solution of at least one monomer.
Dependencies are inferred from the claim text.