Abluminal, multilayer coating constructs for drug-delivery stents

(canceled)

A structural element of an implantable medical device, a surface of the structural element comprises an abluminal side, a luminal side, and two side-walls extending between the abluminal side and the luminal side, wherein the structural element has a coating comprising:

• a continuous first layer disposed above all or a majority of the abluminal side and optionally above a portion of at least one of the side-walls extending from the abluminal side, wherein the luminal side and portions of the sidewalls are free from the first layer;
• and
• a continuous second layer covering a portion of the first layer such that at least a portion of the first layer is not covered by the second layer, wherein a surface of the structural element below the coating is cavity free.

(canceled)

A structural element of an implantable medical device, a surface of the structural element comprises an abluminal side, a luminal side, and two sidewalls extending between the abluminal side and the luminal side, wherein the structural element has a coating comprising:

• a continuous first layer disposed above all or a majority of the abluminal side and optionally above a portion of at least one of the side-walls extending from the abluminal side, wherein the luminal side and portions of the sidewalls are free from the first layer;
• and
• a continuous second layer covering the first layer such that no portion of the first layer is not covered by the second layer, and wherein the luminal side of the structural element is free from the second layer, wherein at least one of the layers is a reservoir layer comprising 40-O-(2-hydroxy)ethyl-rapamycin, 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and/or 40-O-tetrazole-rapamycin.

A structural element of an implantable medical device, a surface of the structural element comprises an abluminal side, a luminal side, and two sidewalls extending between the abluminal side and the luminal side, wherein the structural element has a coating comprising:

• a continuous first layer disposed above all or a majority of the abluminal side and optionally above a portion of at least one of the side-walls extending from the abluminal side, wherein the luminal side and portions of the sidewalls are free from the first layer;
• and
• a continuous second layer covering a portion of the first layer such that at least a portion of the first layer is not covered by the second layer, wherein at least one of the layers is a reservoir layer comprising 40-O-(2-hydroxy)ethyl-rapamycin, 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, and/or 40-O-tetrazole-rapamycin.

A structural element of an implantable medical device, a surface of the structural element comprises an abluminal side, a luminal side, and two sidewalls extending between the abluminal side and the luminal side, wherein the structural element has a coating comprising:

• a continuous first layer disposed above all or a majority of the abluminal side and optionally above a portion of at least one of the side-walls extending from the abluminal side, wherein the luminal side and portions of the sidewalls are free from the first layer;
• and
• a continuous second layer covering a portion of the first layer such that at least a portion of the first layer is not covered by the second layer, wherein the first layer comprises a primer layer, the second layer comprises a reservoir layer, and the third layer comprises a topcoat layer and/or biobeneficial layer.