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AssigneeYeda Research and Development Co. Ltd.
InventorsYoram Salomon, Michal Neeman, Avigdor Scherz, Shimon Gross, Assaf Gilad
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An online Blood Oxygenation Level-Dependent (BOLD)-magnetic resonance imaging (MRI) method for functional clinical guidance or monitoring a therapeutic modality involving treatment by a sensitizer which, upon excitation by the appropriate sensitizing radiation, initiates local oxygen consumption, comprising: (i) generating a BOLD-weighted MR-image of the target region of interest within the patient's body (time t0); (ii) administering said sensitizer to the patient; (iii) irradiating the target region while the patient is subjected to continuous MR imaging; (iv) generating a sole or a plurality of T2* weighted sequential BOLD MR-images during and/or after irradiation (time t); (v) processing the data generated at time t0 and time t and generating a color-coded difference or ratio map on a pixel by pixel basis; and (vi) analyzing the processed data. The method is preferably applied to photodynamic therapy (PDT).
An online Blood Oxygenation Level-Dependent (BOLD)-magnetic resonance imaging (MRI) method for functional clinical guidance or monitoring and follow-up of treatment progression of a therapeutic modality involving treatment by a sensitizer which, upon excitation by the appropriate sensitizing radiation, initiates local oxygen consumption or depletion, said method comprising:
A BOLD-MRI method for online imaging a diseased region within a patient's body for functional clinical guidance prior to a therapeutic treatment of a disease or disorder treatable by local embolization or recanalization, said treatment involving a blood-borne or interstitial electromagnetic radiation-excitable agent (herein designated “sensitizer”) which, upon excitation by the appropriate radiation, initiates local oxygen consumption or depletion, which comprises administering to the patient subjected to continuous MR imaging while placed in the magnetic field of an MRI spectrometer, a non-therapeutic sub-destructive dose of said sensitizer, irradiating the target diseased region with the appropriate sensitizing radiation, and analyzing the changes in the BOLD-MR contrast generated by oxygen consumption in response to excitation of the sensitizer in the diseased region by comparison with an MR-image of the diseased region generated before administration of the sensitizer.
A BOLD-MRI method for online imaging a diseased region of the body in the course of a therapeutic treatment of a disease or disorder treatable by local embolization or recanalization, said treatment involving a blood-borne or interstitial electromagnetic radiation-excitable agent (herein designated “sensitizer”) which, upon excitation by the appropriate radiation initiates local oxygen consumption or depletion, which comprises administering to a patient subjected to continuous MR imaging while placed in the magnetic field of an MRI spectrometer, a therapeutic dose of said sensitizer, irradiating the target diseased region with the appropriate sensitizing radiation, and analyzing the changes in the BOLD-MRI contrast generated by oxygen consumption in response to excitation of the sensitizer in the diseased region by comparison with an MR-image of the diseased region generated before administration of the sensitizer.
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Dependencies are inferred from the claim text.