Trisubstituted nitrogen modulators of tyrosine phosphatases

A compound that has the formula I:

• or a pharmaceutically acceptable derivative thereof, wherein:
• L1, L2 and L3 are independently selected from:
• N—C single bond (i.e. G1, G2, or G3 are directly bonded to N by a single bond), alkylene, alkenylene, alkynylene, cycloalkylene, oxocycloalkylene, amidocycloalkylene, heterocyclylene, heteroarylene, C═O, sulfonyl, alkylsulfonyl, alkenylsulfonyl, alkynylsulfonyl, amido, carboxamido, alkylamido, alkylcarboxamido, and alkoxyoxo;
• and
• where each of the above substituents are unsubstituted or substituted with one or more substituents, in one embodiment, one, two, or three substituents, each independently selected from D1, where D1 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocyclyl, heteroaryl, amido, cyano, cyanoalkenyl, amidoalkyl, amidoalkenyl, and oxo;
• G1, G2, and G3 are independently selected from:
• (i) alkyl, alkenyl, alkynyl, aryl, alkaryl, arylalkyl, alkarylalkyl, alkenylaryl, alkylsulfonyl, alkenylsulfonyl, alkynylsulfonyl, amido, alkylamino, alkylaminoaryl, arylamino, aminoalkyl, aminoaryl, alkoxy, alkoxyaryl, aryloxy, alkylamido, alkylcarboxamido, arylcarboxamido, alkoxyoxo, biaryl, alkoxyoxoaryl, amidocycloalkyl, carboxyalkylaryl, carboxyaryl, carboxyamidoaryl, carboxamido, cyanoalkyl, cyanoalkenyl, cyanobiaryl, cycloalkyl, cycloalkyloxo, cycloalkylaminoaryl, haloalkyl, haloalkylaryl, haloaryl, heterocyclyl, heteroaryl, hydroxyalkylaryl, and sulfonyl;
• and
• (ii) G1 and G2 can be linked together to form a cycloalkyl, oxocycloalkyl, cycloalkyloxo, amidocycloalkyl, cycloalkylamido, alkenylaryl, amidoalkenylaryl, and the following groups,
• where J1, J2, J3, and J4 are selected from H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocyclyl, heteroaryl, amido, cyano, cyanoalkenyl, amidoalkyl, amidoalkenyl, oxo, and CH═C(CN)C(O)NH;
• and
• where each of the above substituents are unsubstituted or substituted with one or more substituents, in one embodiment, one, two, or three substituents, each independently selected from M1, where M1 is H, alkyl, alkenyl, alkynyl, aryl, arylalkyl, alkoxy, alkoxyoxo, alkylthia, amino, amido, arylamino, aryloxy, alkylamino, alkylsulfonyl, alkylcarboxyalkylphosphonato, arylcarboxamido, carboxy, carboxyoxo, carboxyalkyl, carboxyalkyloxa, carboxyalkenyl, carboxyamido, carboxyhydroxyalkyl, cycloalkyl, amido, cyano, cyanoalkenyl, cyanoaryl, amidoalkyl, amidoalkenyl, halo, haloalkyl, haloalkylsulfonyl, heterocyclyl, heteroaryl, heteroarylalkyl, heteroarylalkoxy, hydroxy, hydroxyalkyl, hydroxyamino, hydroxyimino, heteroarylalkyloxa, nitro, phosphonato, phosphonatoalkyl, and phosphonatohaloalkyl.