Quinoline derivatives as nk-2 and nk-3 receptor antagonists

A compound of formula (I)

• wherein:
• R1 is H or substituted or unsubstituted (C1-6)alkyl;
• R2 is substituted or unsubstituted aryl, (C3-7)cycloalkyl, or heterocycle;
• R3 is H or substituted or unsubstituted (C1-6)alkyl, (C3-7)cycloalkyl, aryl or heterocycle;
• A is NR8 or O;
• R8 is H or substituted or unsubstituted (C1-6)alkyl;
• R4 is substituted or unsubstituted heterocycle;
• R5 is H or up to three substitutents independently selected from the list consisting of alkyl, alkenyl, aryl, alkoxy, or a hydroxylated deriviative thereof, hydroxy, halogen, nitro, cyano, carboxy, alkylcarboxy, alkylcarboxyalkyl, haloalkyl, amino or mono- or dialkylamino;
• or R5 represents a bridging moiety which is arranged to bridge two adjacent ring atoms, wherein the bridging moiety comprises alkyl or dioxyalkylene;
• R6 is H or halo;
• R7 is oxo;
• n is 1 to 4;
• or a pharmaceutically acceptable salt thereof.