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US 2006/0135765 A1Published application
Antineoplastic ether lipid compounds
OwnerWalter Perkinsinventor
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Abstract
Ether lipid compounds of formula (1): Formula (I) pharmaceutically-acceptable salts, prodrugs or isomers thereof are provided, where the variables are as defined herein. The compounds of the invention have anti-neoplastic activity, and accordingly have utility in treating cancer and related diseases. Enantiomers of these compounds, pharmaceutical compositions, and methods for treating cancer with the pharmaceutical compositions are also provided.
Claims28
An ether lipid having formula (I), or a pharmaceutically acceptable salt, isomer or prodrug thereof:
- wherein
- R1 is selected from the group consisting of —C18H37 and —CH2CH2(OCH2CH2)mO—CH3;
- R2 and R3 are each independently selected from the group consisting of
- X1 is selected from the group consisting of
- X2 is selected from the group consisting of:
- n is 0 or 1;
- and
- m is 0 or an integer from 1 to 10.
5 more elements
Dependencies are inferred from the claim text.