Mammalian cell surface antigens; related reagents
AssigneeSchering Corporation
InventorsDaniel Gorman, Troy Randall, Albert Zlotnik
Life of this patent
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Abstract
Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
Claims22
A substantially pure or recombinant 312C2 protein or conservatively modified variants thereof, said protein:
- a) is expressed on activated T cells;
- or
- b) specifically binds to antibodies generated against. SEQ ID NO:
- 2 or 4.
A recombinant nucleic acid comprising sequence at least about 70% identity over a stretch of at least about 30 nucleotides to a 312C2 nucleic acid sequence of SEQ ID NO:
- 1 or 3.
A method of treating a host mammal having an abnormal immune response by administering to said mammal an effective dose of:
- a) an antibody or binding partner which binds specifically to a 312C2;
- b) a substantially pure 312C2 protein or peptide thereof;
- or
- c) a nucleic acid encoding a 312C2 peptide.
Dependencies are inferred from the claim text.