Antimicrobial peptide isolated from halocynthia aurantium
AssigneeIndustry-Academic Cooperation Foundation, Hoseo University
InventorsIn-Hee Lee, Seok-Min Son, Woong-Sik Jang, Kyu-Nam Kim
Life of this patent
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Abstract
The present invention relates to an antimicrobial peptide isolated from Halocynthia aurantium, more particularly, to an antimicrobial peptide isolated from the body fluid of Halocynthia aurantium and an antimicrobial agent comprising the same as an active ingredient. The antimicrobial peptide of the present invention shows excellent antimicrobial activity under strong acidic and basic environments. Moreover, it also shows strong antimicrobial activity against resistant bacteria. So, it can be used usefully as a natural antimicrobial agent.
Claims11
A peptide separated from tunicate and comprising amino acid sequence represented by the below <Chemical Formula 1> in which each amino acid is represented by each figure;
- W1X2B′3U4X5X6B7B8U9X10B′11C12U13B14U15X16X17U18 <Chemical Formula 1>
- In the above Formula,
- W represents tryptophane or its derivatives;
- X represents more than one amino acid residue selected from a group consisting of tyrosine, valine, isoleucine, methionine, phenylalanine and tryptophane, and the derivatives thereof;
- B represents more than one amino acid residue selected from a group consisting of arginine, lysine and histidine, and the derivatives thereof;
- B′ represents more than one amino acid residue selected from a group consisting of arginine, lysine and histidine or from a group consisting of asparagine and glutamine, and the derivatives thereof;
- and
- U represents more than one amino acid residue selected from a group consisting of glysine, serine, alanine and threonine, and the derivatives thereof.
A peptide comprising amino acid sequence represented by the below <Chemical Formula 2> in which three amino acids (W1X2B′3) of the peptide represented by the above <Chemical Formula 1> are lost;
- U4X5X6B7B8U9X10B′11C12U13B14U15X16X17U18 <Chemical Formula 2>
- In the above Formula,
- U represents more than one amino acid residue selected from a group consisting of glysine, serine, alanine and threonine, and the derivatives thereof;
- X represents more than one amino acid residue selected from a group consisting of tyrosine, valine, isoleucine, leucine, methionine, phenylalanine and tryptophane, and the derivatives thereof;
- B represents more than one amino acid residue selected from a group consisting of arginine, lysine and histidine, and the derivatives thereof;
- and
- B′ represents more than one amino acid residue selected from a group consisting of arginine, lysine and histidine or from a group consisting of asparagine and glutamine, and the derivatives thereof.
An antimicrobial agent comprising one or more peptides selected from a group consisting of compounds represented by <Chemical Formula 1-5> as an active ingredient.
Dependencies are inferred from the claim text.